Mouse studies hint at a way to treat age-related decline
A single molecule may play a central role in rejuvenating aging brains, albeit in multiple ways, new research suggests.
Studies in mice of three different techniques for combating the cognitive decline that accompanies aging found that they all increase levels of a protein called platelet factor four, or PF4. This in turn improved cognitive performance and biological signs of brain health, three research groups report August 16 in Nature Aging, Nature and Nature Communications.
“PF4 may be an effective factor, and this kind of work will help bring it toward a therapeutic agent” for age-related cognitive decline, says bioengineer Michael Conboy of the University of California, Berkeley, who wasn’t involved in the work.
One of the research groups, led by neuro-scientist Dena Dubal of the University of California, San Francisco, was studying klotho, a hormone linked to longevity. Injecting the hormone into mice boosts cognition, but since klotho is too large to cross the blood-brain barrier, it must act on the brain indirectly via a messenger.
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