The Vast Potential of the Vagus Nerve | LENS treatment in White Plains

Some say a cure for ailments like anxiety is flowing from the brain. But much is unknown.

By Christina Caron

In recent years, the vagus nerve has become an object of fascination, especially on social media. The vagal nerve fibers, which run from the brain to the abdomen, have been anointed by some influencers as the key to reducing anxiety, regulating the nervous system, and helping the body to relax.

TikTok videos with the hashtag “#vagusnerve” have been viewed more than 64 million times, and there are nearly 70,000 posts with the hashtag on Instagram. Some of the most popular ones feature simple hacks to “tone” or “reset” the vagus nerve, in which people plunge their faces into ice water or lie on their backs with ice packs on their chests.

Now, wellness companies have capitalized on the trend, offering products like vagus massage oil, pillow mists, and vibrating bracelets. These products claim to stimulate the nerve, but they have not been endorsed by the scientific community.

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Strong bones may be vital for maintaining memory in old age

A hormone released by bones seems to reverse age-related memory loss. The hormone can be boosted by exercise, suggesting that lifting weights might protect the brain from the ravages of old age.

Eric Kandel of Columbia University in New York and colleagues were interested in understanding the mechanisms behind normal age-related memory loss.

To investigate, they measured mRNA levels associated with the expression of 23,000 genes in human brain tissue. Genes use mRNA to tell cells to make products such as proteins – mRNA levels therefore reflect how active a gene was before death.

The team focused their analysis on the dentate gyrus, a brain region particularly affected by memory loss as we grow older.

The brain tissue came from eight healthy people aged between 33 and 88. Across these people, one gene — called RbAp48 — became steadily less active with age. This gene is known to be involved in the process by which we turn short-term memories into long-term memories.

Health bones, healthy brain

Kandel’s team went on to show that a relationship exists between RbAp48 and osteocalcin, a hormone secreted by bone.

Osteocalcin has many functions, one of which seems to be involved in cognition – mice who carry a mutation that makes them deficient in the hormone have memory deficits. Replacing this hormone improves their memory.

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