In a Q & A article in the New York Times titled ‘Pain Medications Can Lose Their Punch’, the question was asked: Why would a pain medication lose its efficiency after working well for several years?
In his response Dr Shahil Ahmed, a pain medicine specialist at New York-Presbyterian Hospital / Weill Cornell Medical Center, replied: ‘ It is due to a phenomenon called tolerance., in which there is a decrease in response over time to repeated exposures of the body to pain medication. ‘This might be due to drug interactions, or bodily changes add a substance that induces an enzyme responsible for disposing of the drug.’ Other causes include increase in nervous system receptors, called NMDA receptors.
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