Wednesday, October 25, 2023

Protein linked to brain rejuvenation

Mouse studies hint at a way to treat age-related decline

A single molecule may play a central role in rejuvenating aging brains, albeit in multiple ways, new research suggests.

Studies in mice of three different techniques for combating the cognitive decline that accompanies aging found that they all increase levels of a protein called platelet factor four, or PF4. This in turn improved cognitive performance and biological signs of brain health, three research groups report August 16 in Nature Aging, Nature and Nature Communications.

“PF4 may be an effective factor, and this kind of work will help bring it toward a therapeutic agent” for age-related cognitive decline, says bioengineer Michael Conboy of the University of California, Berkeley, who wasn’t involved in the work.

One of the research groups, led by neuro-scientist Dena Dubal of the University of California, San Francisco, was studying klotho, a hormone linked to longevity. Injecting the hormone into mice boosts cognition, but since klotho is too large to cross the blood-brain barrier, it must act on the brain indirectly via a messenger.

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Wednesday, October 18, 2023

Alternatives to drug treatment for pain – radio frequency | Neurofeedback Practitioner

In a Q & A article in the New York Times titled ‘Pain Medications Can Lose Their Punch’, the question was asked: Why would a pain medication lose its efficiency after working well for several years?

In his response Dr Shahil Ahmed, a pain medicine specialist at New York-Presbyterian Hospital / Weill Cornell Medical Center, replied: ‘ It is due to a phenomenon called tolerance., in which there is a decrease in response over time to repeated exposures of the body to pain medication. ‘This might be due to drug interactions, or bodily changes add a substance that induces an enzyme responsible for disposing of the drug.’ Other causes include increase in nervous system receptors, called NMDA receptors.

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Neurofeedback for Everyday Stress Management

In today’s fast-paced world, stress has become a constant companion for many. From work deadlines to personal responsibilities, managing str...