Protein linked to brain rejuvenation

Mouse studies hint at a way to treat age-related decline

A single molecule may play a central role in rejuvenating aging brains, albeit in multiple ways, new research suggests.

Studies in mice of three different techniques for combating the cognitive decline that accompanies aging found that they all increase levels of a protein called platelet factor four, or PF4. This in turn improved cognitive performance and biological signs of brain health, three research groups report August 16 in Nature Aging, Nature and Nature Communications.

“PF4 may be an effective factor, and this kind of work will help bring it toward a therapeutic agent” for age-related cognitive decline, says bioengineer Michael Conboy of the University of California, Berkeley, who wasn’t involved in the work.

One of the research groups, led by neuro-scientist Dena Dubal of the University of California, San Francisco, was studying klotho, a hormone linked to longevity. Injecting the hormone into mice boosts cognition, but since klotho is too large to cross the blood-brain barrier, it must act on the brain indirectly via a messenger.

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Alternatives to drug treatment for pain – radio frequency | Neurofeedback Practitioner

In a Q & A article in the New York Times titled ‘Pain Medications Can Lose Their Punch’, the question was asked: Why would a pain medication lose its efficiency after working well for several years?

In his response Dr Shahil Ahmed, a pain medicine specialist at New York-Presbyterian Hospital / Weill Cornell Medical Center, replied: ‘ It is due to a phenomenon called tolerance., in which there is a decrease in response over time to repeated exposures of the body to pain medication. ‘This might be due to drug interactions, or bodily changes add a substance that induces an enzyme responsible for disposing of the drug.’ Other causes include increase in nervous system receptors, called NMDA receptors.

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Scientists extract music from the mind

A computer model used brain data to re-create a Pink Floyd song

In what seems like something out of a sci-fi movie, scientists have plucked the famous Pink Floyd song “Another Brick in the Wall” from individuals’ brains.

Previously, researchers have used electrodes, computer models and brain scans to decode and reconstruct individual words and entire thoughts from peoples brain activity (SN: 6/3/23, P. 14).

The new study, published August 15 in PLOS Biology, adds music into the mix, showing that songs can also be decoded from brain activity and revealing how different brain areas pick up an array of acoustic elements. The finding may eventually help improve communication devices used by people with paralysis or other conditions that limit the ability to speak.

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Science visualized

A classic brain map gets an update

The traditional view of how the human brain controls voluntary movement might not tell the whole story.

The motor homunculus, a diagram of the primary motor cortex, has reigned supreme in neuroscience since the 1930s. It shows how this narrow brain region is divided into sections, each assigned to a body part that can be controlled voluntarily. The space each part spans on the motor cortex is proportional to how much control one has over that part.

A new map reveals that in addition to having regions devoted to specific body parts, three newfound areas control integrative, whole-body actions. And representations of where specific body parts fall on this map are organized differently than previously thought, researchers report in the May 11 Nature.

For decades, research in monkeys has hinted that something about the classic view was amiss. Scientists conducting this research "have known for 50 years that the homunculus isn't quite right," says Evan Gordon, a neuroscientist at Washington University School of Medicine in St. Louis.

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Brains may have a playfulness switch

Blocking the activity of certain cells reduces play behavior in rats.

Rats are extremely playful creatures.They love playing chase and they literally jump for joy when tickled. Central to this play- fulness, a new study finds, are nerve cells in a specific region of the brain.

Neurons in the periaqueductal gray, or PAG, are active in rats during different kinds of play, scientists report July 28 in Neuron. Blocking the activity of those neurons makes the rodents much less playful.

The results give insight into a poorly understood behavior, particularly in terms of how play is controlled in the brain.

When scientists tickled lab rats (one shown) and played a game with them, nerve cells in a brain region called the PAG became active. The team suspects that this region controls playfulness.“There are prejudices that it’s childish and not important, but play is an underrated behavior,” says Michael Brecht, a neuro- scientist at Humboldt University of Berlin.

Scientists think play helps animals develop resilience. Some researchers even relate the behavior to optimal functioning, For people, “when you’re playing, you’re being your most creative, thoughtful, interactive self)” says Jeffrey Burgdorf, a neuroscientist at Northwestern University in Evanston, Ill., who was not involved in the study. This is the opposite of some depressive states, and Burgdorf’s own research aims to turn understanding of the neuroscience of play into new therapies for mood disorders. In the study, Brecht and colleagues got lab rats used to being tickled and played with in a game of chase-the-hand.

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Light My Fire by Lynne McTaggart | Neurofeedback Practitioner

I’ve been bowled over by new advancements in energy medicine. American chiropractor Carol McMakin has achieved the seemingly impossible with patients suffering chronic pain and many other conditions after developing equipment that can deliver specific microcurrent frequencies to the body.

There’s also new research with infrared light showing extraordinary promise for healing everything from a bad gut and heart conditions to Parkinson’s and Alzheimer’s. Research has suggested that this light could have a direct effect on our immune and inflammatory systems.

Although the two systems work very differently, they are founded on a similar principle: the body as an energetic system Communicating profoundly affected by electromagneticism.

Although members of the medical community have been astounded by evidence of the effectiveness of both systems to stimulate mitochondrial’ and ATP energy production in the cells_at specific frequencies the idea of the body electric is nothing new.

It was the Russi an scientist Alexander Gurwitsch who is credited with first discovering what he called ‘mitogenetic radiation’ in onion roots in the 1920s. Gurwitsch postulated that a field, rather than chemicals alone, was probably responsible for the structural formation of the body. Although Gurwitsch’s work was largely theoretical, later researchers were able to show that a weak radiation from tissues stimulates cell growth in neighboring tissues of the same organism.

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Safe and Effective Treatment Options for Depression | reducing sleep anxiety

Do you suffer from pessimism, low energy, low mood, sadness? Are you unmotivated, oversleeping, having feelings of worthlessness, even despair? Or do you have mood swings, agitation, emotional reactivity, and fatigue from anxiety with depression?

In any one year, around 60% of the population is suffering from depression. But the good news is that depression is a treatable disease just like a physical illness.

People suffering from anxiety and depression find it difficult to take the first step towards treatment. So, if your mental health is to keep you away from your normal lifestyle you need to get help from family members or a health professional.

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